Suitable applications: Oral and topical
Residual solvent: Ethyl acetate
Carbopol® 971P NF polymer was introduced for use in oral and mucosal contact applications such as extended release tablets, oral liquids and bioadhesive formulations. It is a lightly crosslinked polymer with long rheology, which will result in flow like honey in a semisolid formulation.
Carbopol® 971P NF polymer tends to be more efficient in controlling drug release than Carbopol® 974P NF polymer because it is less crosslinked and provides a three dimensional gel structure which is more resistant to diffusion and erosion. Typical usage levels for achieving extended release characteristics in tablets manufactured by aqueous granulation are 5 - 10 wt.%, depending on the drug properties, co-excipients and processing parameters.
Powder and granular grade Carbopol® polymers can be combined in a formulation to achieve various release profiles. The release rates can be modulated by incorporating the powder carbomer (Carbopol® 971P NF or 974P NF polymers) in the granules and then blending with granular carbomer (Carbopol® 71G NF polymer).
Carbopol® 971P NF polymer can be used to formulate low viscosity lotions, gels and liquids with good clarity. Additionally, it can provide emulsion stabilization of lotions.