Applications
Oral Solid Dosage Forms
APPLICATION USAGE
Lubrizol’s polymers are highly efficient gel matrix formers for controlling drug release in tablets, capsules and multiparticulate systems. In many cases Lubrizol ’s polymers have demonstrated slower drug release rates at lower concentrations than other commercially available excipients, enabling overall formulation cost savings and smaller tablet sizes. Additionally, tablet formulations using Carbopol® polymers have demonstrated excellent hardness and low friability over a wide range of compression forces and in many cases linear drug release (zero-order and near zero-order release kinetics).
Carbopol® polymers are widely compatible with commonly used fillers and binders and can be combined with other matrix forming agents if needed to achieve a desired release profile.
Carbopol® polymers are available in both powdered and granular forms, therefore they can be used in all types of tablet manufacturing processes. For example, powder Carbopol® polymers can efficiently be used in a roller compaction process and a variety of granulation technologies. A free-flowing granular product, Carbopol® 71G NF polymer, is also available for use in direct compression processes. Also, Carbopol® 71G NF polymer can be added extragranularly to improve the release performance of a formulation.
Lubrizol polymers are currently used or are being evaluated for use as taste masking agents, tablet binders, coating excipients and bioadhesive dosage forms for targeted drug delivery.
APPLICATION ADVANTAGES
- The only granular carbomer available for direct compression formulations (Carbopol® 71G NF polymer)
- Efficient control release agents for matrix tablets
- Improve bioavailability of certain drugs
- Efficient binder in dry granulation processes (slugging or roller compaction)
- Efficient binder in wet granulation processes
