Applications
Bulk Laxatives
APPLICATION USAGE
Noveon® calcium polycarbophils are active pharmaceutical ingredients used in bulk laxative tablets. Calcium polycarbophil is approved by the U.S. Food and Drug Administration (U.S. FDA) as an over-the-counter treatment for constipation associated with conditions such as irritable bowel syndrome.
Calcium polycarbophil remains a non-bioadhesive salt in the mouth, partially acidifies to polycarbophil in the stomach and neutralizes and swells in the intestine. The swollen polycarbophil then acts as a bulk laxative.
Two product grades are offered, a coarsely-milled grade for formulation of swallowable bulk laxative tablets/capsules and a finely-milled grade for formulation of chewable tablets or lozenges.
APPLICATION ADVANTAGES
- Safe and effective
- Inert (not absorbed or metabolized by the body)
- Remarkable water binding action to alleviate constipation
- Not fermented or transformed by bacteria in the colon, therefore cramping and bloating are less common than with other bulking agents
